Vaccination During Pregnancy: Protecting the Mother and Baby

Fictional image, for illustrative purposes only.
Pregnancy is a special time for every woman, filled with joy and preparations for the arrival of a new baby. However, it is also a period when both the mother and baby are vulnerable to various health risks. One important way to ensure their well-being is through timely vaccinations1.
Many infectious diseases pose serious risks to both the expecting mother and the baby, but vaccinations help build immunity and reduce these concerns. In addition to protecting the mother’s health, vaccinations also provide essential immunity to the baby during first few months of life.1
By understanding the importance of vaccination during pregnancy, as recommended by the Federation of Obstetric and Gynaecological Societies of India (FOGSI)8, and consulting their doctor about maternal immunisation, expectant mothers can take proactive steps to protect both themselves and their babies from diseases.
The Importance of Vaccination During Pregnancy
1. Pregnancy Increases Health Risks for Mothers
During pregnancy, a woman’s immune, heart, and respiratory systems undergo major changes, making her more vulnerable to certain illnesses1. For example, the risk of flu complications increases, particularly in the second and third trimesters. The flu can also affect the unborn baby, possibly leading to premature birth and low birth weight1,2. These complications can often be prevented with vaccination, which strengthens the mother’s immune system and helps the body fight off serious infectious diseases9.
2. Newborns Are Highly Vulnerable in Their First Weeks
Newborns are especially prone to infections in their early weeks because their immune systems are not yet fully developed. Some serious diseases cannot be prevented with direct vaccination at birth, and the risk of fatal infections is highest during this period. This makes it even more important for mothers to get vaccinated during pregnancy, as it helps protect their babies from life-threatening illnesses1.
3. Pregnant Women Pass Protective Antibodies to Their Babies
Mothers naturally pass protective antibodies to their babies during pregnancy. This transfer begins in the second trimester and increases in the third trimester, with antibodies moving through the placenta to help the baby fight infections after birth. However, for the baby to receive adequate protection, the mother must have a strong immune response. Vaccination during pregnancy ensures that mothers pass on essential antibodies (passive immunity), helping to safeguard newborns until their immune systems mature1.
Which Diseases Can Vaccination During Pregnancy Protect the Mother and Child Against?
Now that you have learned that maternal immunisation is essential for protecting both the mother and baby from serious infectious diseases 1, let’s understand the diseases that vaccinations can help prevent:
1. Pertussis (Whooping Cough)
Pertussis is a highly contagious respiratory illness caused by Bordetella pertussis, which only infects humans. It spreads easily through airborne droplets from an infected person3.
Common Symptoms3,4:
- Starts with mild cold-like symptoms:
- Runny or stuffy nose
- Low fever
- Mild cough
- Can worsen to:
- Severe, long-lasting coughing fits
- Breathing difficulties
- Pneumonia (in serious cases)
Why Vaccination?
Newborns are particularly vulnerable as they cannot be vaccinated at birth. The Tdap vaccination during pregnancy helps pass immunity to the baby, reducing the risk of severe illness and mortality in the first few months of life3,5.
2. Diphtheria
Diphtheria is a bacterial infection caused by Corynebacterium diphtheriae that primarily spreads through respiratory droplets. It mainly affects the skin and mucous membranes and can lead to severe complications6.
Common Symptoms6
- Sore throat
- Fever
- Swelling of the neck
- Thick grey membrane over the throat and tonsils, which can block the airway and cause severe breathing difficulties
Why Vaccination?
Diphtheria can lead to breathing difficulties, heart complications, and nerve damage. In severe cases, it may spread into the bloodstream, resulting in life-threatening complications. The Tdap vaccination provides essential protection for both the mother and baby by reducing the risk of infection and associated complications6,1.
3. Tetanus
Tetanus is a severe bacterial infection caused by Clostridium tetani, a bacterium commonly found in soil. The bacteria enter the body through open wounds, including burns, bites, ulcers, and even minor cuts or scratches7.
Common Symptoms7
- Muscle stiffness and spasms
- Lockjaw (inability to open the mouth)
- Difficulty swallowing
- Severe muscle contractions
Why Vaccination?
Tetanus affects the nervous system and can be life-threatening, especially for newborns (neonatal tetanus). Vaccination is the only effective way to prevent tetanus infection7,1.
4. Influenza (Flu)
Influenza is a common yet serious viral infection that spreads through respiratory droplets, affecting the nose, throat, and lungs10.
Common Symptoms10:
- Fever
- Cough
- Sore throat
- Fatigue
- Muscle aches

Fictional image, for illustrative purposes only.
Why Vaccination?
Pregnant women are at a higher risk of severe complications and hospitalisation due to immune system changes1. Additionally, influenza increases the risk of premature birth and low birth weight. The influenza vaccination in pregnancy is an effective preventive measure that protects both the mother and baby from severe illness and its associated complications9.
Recommended Vaccination Schedule for Pregnant Women
The Federation of Obstetric and Gynaecological Societies of India (FOGSI) provides specific guidelines on vaccinations during pregnancy. Below is the recommended vaccination schedule for pregnant women8:
Vaccination |
Type of Vaccination |
Interval |
Td1/TT1 |
Tetanus, diphtheria toxoid |
Early in pregnancy |
Td2/Tdap |
Tetanus, diphtheria toxoid and acellular pertussis |
27–36 weeks |
Influenza (IIV) |
Inactivated vaccination |
26 weeks onwards/Any time in pregnancy if the risk of influenza is high |
The pregnancy vaccination chart above is based on recommendations from the Federation of Obstetric and Gynaecological Societies of India8.
Conclusion
Vaccination during pregnancy is recommended to protect the health of both the mother and the baby. By preventing serious diseases like pertussis, influenza, tetanus, and diphtheria, immunisation lowers the risk of complications, reduces the severity of illnesses, and provides newborns with early immunity1.
Consult your doctor about getting vaccinated during pregnancy against pertussis (whooping cough), diphtheria, tetanus, and influenza (flu).
Frequently Asked Questions (FAQs)
1. Are vaccinations safe for pregnant women?
Yes, vaccinations are safe for pregnant women. While some may experience mild side effects such as fever, fatigue, or soreness at the injection site, these effects are temporary. The benefits of vaccination outweigh any known or potential risks1.
2. What happens if I don’t get vaccinated during pregnancy?
If you are not vaccinated during pregnancy, you and your baby may face a higher risk of serious infections such as pertussis, flu, tetanus, and diphtheria1. These illnesses can cause complications, including premature birth, low birth weight, severe illness, or even death in newborns9. Vaccination is a safe and effective way to protect both you and your baby from these risks1,2.
3. When should I get the recommended vaccinations?
According to FOGSI, the following vaccination schedule is advised for pregnant women8:
- Td1/TT1 (Tetanus, Diphtheria Toxoid): Early in pregnancy
- Td2/Tdap (Tetanus, Diphtheria, Pertussis): Between 27–36 weeks of pregnancy
- Influenza (IIV) (Flu): From 26 weeks onward (or earlier for high-risk individuals)
4. Can I receive multiple vaccinations at once?
Yes, it is safe to receive multiple vaccinations at the same time during pregnancy1,8. Please consult your doctor to learn more about vaccination and pregnancy.
5. Do vaccinations affect breastfeeding?
Most vaccinations are safe during breastfeeding and do not harm the baby1. However, please consult your doctor about the vaccinations.
References
- CDC. (2025, February 19). About vaccines and pregnancy. Pregnancy and Vaccination. https://www.cdc.gov/vaccines-pregnancy/about/index.html
- MacDonald, N. E., McDonald, J. C., & Canadian Paediatric Society, Infectious Diseases and Immunization Committee. (2014). The benefits of influenza vaccine in pregnancy for the fetus and the infant younger than six months of age. Paediatrics & Child Health, 19(9), e121-2. https://doi.org/10.1093/pch/19.9.e121
- CDC. (2025a, January 30). About whooping cough. Whooping Cough (Pertussis). https://www.cdc.gov/pertussis/about/index.html
- CDC. (2024, October 23). Symptoms of whooping cough. Whooping Cough (Pertussis). https://www.cdc.gov/pertussis/signs-symptoms/index.html
- CDC. (2025, February 13). Tdap vaccination for pregnant women. Whooping Cough (Pertussis). https://www.cdc.gov/pertussis/vaccines/tdap-vaccination-during-pregnancy.html
- Lamichhane, A., & Radhakrishnan, S. (2025). Diphtheria. In StatPearls. StatPearls Publishing.
- Verma, R., Khanna, P., & Dhankar, M. (2016). Vaccination during pregnancy: Today’s need in India. Human Vaccines & Immunotherapeutics, 12(3), 668–670. https://doi.org/10.1080/21645515.2015.1093265
- (N.d.). Fogsi.org. Retrieved March 20, 2025, from https://www.fogsi.org/wp-content/uploads/2024/08/Binder_Vaccination-in-Women.pdf
- Dorélien A. The Effects of In Utero Exposure to Influenza on Birth and Infant Outcomes in the US. Popul Dev Rev. 2019 Sep;45(3):489-523.
- CDC. Influenza (Flu) [Internet]. Centers for Disease Control and Prevention. 2024. from: https://www.cdc.gov/flu/about/index.html
CL code: NP-IN-PVU-WCNT-250005 DoP: March 2025
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